Alpha Synuclein Products
StressMarq’s alpha synuclein pre-formed fibrils (PFFs) seed the formation of new fibrils from active alpha synuclein monomers, and can be used to induce endogenous alpha synuclein phosphorylation and subsequent Lewy body inclusion formation in neuronal cell culture or for in vitro oligomerization studies.
Product Description | Catalog No. | Monomer Source |
---|---|---|
Human Alpha Synuclein Pre-formed Fibrils (Type 1) | SPR-322 | Human Alpha Synuclein Monomers (SPR-321) |
Human Alpha Synuclein Pre-formed Fibrils (ATTO 594 conjugated, Type 1) | SPR-322-A594 | Human Alpha Synuclein Monomers (SPR-321) |
Mouse Alpha Synuclein Pre-formed Fibrils (Type 1) | SPR-324 | Mouse Alpha Synuclein Monomers (SPR-323) |
Human Alpha Synuclein Pre-formed Fibrils (Type 2) | SPR-317 | Human Alpha Synuclein Monomers (Type 2) (SPR-316) |
Human Alpha Synuclein N-Terminal Acetylated Pre-formed Fibrils (Type 1) | SPR-332 | Human N-Terminal Acetylated Alpha Synuclein Monomers (SPR-331) |
Human Alpha Synuclein A53T Mutant Pre-formed Fibrils (Type 1) | SPR-326 | Human Alpha Synuclein A53T Mutant Monomers (Type 1) (SPR-325) |
Human Alpha Synuclein S87N Mutant Pre-formed Fibrils | SPR-500 | Human Alpha Synuclein S87N Mutant Monomers (Type 1) (SPR-499) |
Human Alpha Synuclein S129A Mutant Pre-formed Fibrils | SPR-506 | Human Alpha Synuclein S129A Mutant Monomers (SPR-505) |
Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils | SPR-504 | Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Monomers (SPR-503) |
Rat Alpha Synuclein Pre-formed Fibrils | SPR-482 | Rat Alpha Synuclein Monomers (SPR-481) |
Human Alpha Synuclein Filaments (Immature Fibrils) | SPR-450 | Human Alpha Synuclein Monomers (SPR-321) |
Product Name | Catalogue No. |
---|---|
Human Alpha Synuclein Monomers (Type1) | SPR-321 |
Human Alpha Synuclein Monomers (Type 2) | SPR-316 |
Mouse Alpha Synuclein Monomers (Type 1) | SPR-323 |
Human Alpha Synuclein A53T Mutant Monomers (Type 1) | SPR-325 |
Human Alpha Synuclein S87N Mutant Monomers | SPR-499 |
Human Alpha Synuclein S129A Mutant Monomers | SPR-505 |
Human Alpha Synuclein TNG (A53T, S87N, N103G0 Mutant Monomers | SPR-503 |
Human Alpha Synuclein N-Terminal Acetylated Monomers (Type 1) | SPR-331 |
Rat Alpha Synuclein Monomers | SPR-481 |
Catalog | Target | Clone | Host | Applications | Reactivity |
---|---|---|---|---|---|
SMC-530 | Alpha Synuclein | 3C11 | Mouse | WB, DB, ICC/IF, ELISA | Hu, Ms, Rt |
SMC-531 | Alpha Synuclein | 10H7 | Mouse | WB, DB, ICC/IF, ELISA | Hu, Ms, Rt |
SMC-532 | Alpha Synuclein | 3F8 | Mouse | WB, DB, ICC/IF, IHC, ELISA | Hu, Ms, Rt |
SMC-533 | Alpha Synuclein | 4F1 | Mouse | WB, DB, ICC/IF, IHC, ELISA | Hu, Ms, Rt |
SMC-600 | Alpha Synuclein | J18 | Rabbit | WB, ICC/IF, IHC, ELISA | Hu, Ms |
SPC-742 | Alpha Synuclein (pSer129) | PAb | Rabbit | WB, ELISA | Hu, Ms, Rt |
SPC-800 | Alpha Synuclein | PAb | Rabbit | WB, ICC/IF, IHC, ELISA | Hu, Ms, Rt |
SPC-1435 | Alpha Synuclein (pTyr136) | PAb | Rabbit | WB | Hu, Ms, Rt |
SMC-617 | Anti-Alpha Synuclein Antibody (Aggregate-Specific) [2F11] | 2F11 | Mouse | WB, DB, IP, IHC, ICC-IF ImmunoGold | Hu, Ms |
Alpha Synuclein Antibody (SMC-531) in SK-N-BE cells
Alpha Synuclein Antibody (SMC-800) in human cerebellum
Domain-Independent Inhibition of CBP/p300 Attenuates α-Synuclein Aggregation.
- Hlushchuk, et al. (2021) ACS Chemical Neuroscience. Online ahead of print.
- Yakubu, U.M., Morano, K.A. (2021) bioRxiv. 296:100567.
- Read more on our blog.
- Verma, D.K. et al. (2020) eNeuro. 0134-20.2020.
Handling Instructions – Learn how to handling alpha synuclein proteins safely and effectively
Thioflavin T Assay Protocol – Thioflavin T is a dye that binds to beta-sheets and allows the for the study of alpha synuclein aggregation.
Cell Culture Assay Protocol – Learn how alpha synuclein can be added to primary neuronal culture to induce Lewy body pathology.
In Vivo Assay – Alpha synuclein PFFs can be injected into rodent brains, where they produce alpha synuclein aggregation and pathology.
Types of Alpha Synuclein Fibrillar Constructs – Learn about different types of our alpha synuclein fibrillar constructs.
Which Alpha Synuclein Construct Should I Use? – A guide to modelling synucleinopathies.
Alpha Synuclein Research Tools Poster – A summary of proteins and antibodies available for alpha synuclein research.
Studying Alzheimer’s and Parkinson’s Disease using Pre-Formed Fibrils – An interview with StressMarq President & CEO Ariel Louwrier about PFFs in neurodegeneration research.
Parkinson’s Disease Models: An Overview of Cellular and Animal Models for Neurodegeneration Research – Learn about the strengths and weaknesses of various disease models available.
Video: Why do we Sonicate Alpha Synuclein Fibrils? – Learn why we recommend sonication of fibrils prior to use in research.
How does Sonication Affect Fibrils? – Detailed information on sonicators and fibril sonication.
A53T Alpha Synuclein – The A53T mutation can enhance alpha synuclein aggregation and has been linked to genetic forms of Parkinson’s.
Alpha Synuclein Phosphorylation at Serine 129 – Learn why pSer129 is used to detect alpha synuclein pathology and how it is relevant to PD.
N-Terminal Acetylated Alpha Synuclein – Learn about how this post translational modification affects alpha synuclein aggregation.
Oligomers – Read about the alpha synuclein oligomer toxicity in synucleinopathies
Alpha Synuclein Monomers – Why target them?
N-terminal Acetylated Alpha Synuclein in Parkinson’s Disease – Learn about the effects of N-terminal acetylation on aggregation.
Alpha Synuclein and Tau: Interactions in Neurodegenerative Diseases – Learn how alpha synuclein and tau can interact to promote each other’s aggregation.
Alpha Synuclein in Parkinson’s Disease – A summary of the role of alpha synuclein and how it can contribute to PD pathogenesis.
Alpha Synuclein in Parkinson’s Disease Diagnostics – Learn how alpha synuclein can be used as a biomarker to improve disease diagnostics.
Alpha Synuclein in Parkinson’s Disease Therapeutics – Treatment approaches to targeting alpha synuclein in Parkinson’s Disease.
Alpha Synuclein Oligomers: Dopamine Stabilization and Neurodegeneration – Learn why oligomers are thought to be toxic and how dopamine is involved in their toxicity