Neuroscience

Focus Biomolecules

Paired Targets (Plus Antibody)

Prostratin–

A PKC activator that induces differentiation and neuro-regeneration

GFAP  – Often elevated during glial activation

Caspase-3 – Triggers stress/apoptotic pathways in neurons and glia

ISRIB–

An integrated stress response inhibitor

Amyloid Beta  – ISRIB shows potential to attenuate AB-induced neuronal cell death

Tau (MAPT) – ISR modulation is linked with reversal of tauopathy phenotypes

UAMC-4821 (ferroptosis inhibitor)–

A next-generation ferrostatin-like inhibitor with oral bioavailability and BBB penetration

Neurofilament Light (NfL – Axonal injury marker influenced by ferroptosis stress

Intelliscreen™ Neuropathic Pain Ion Channel Library–

Contains blockers of sodium, calcium, TRP, P2X, NMDA, and AMPA channels involved in pain signalling

GFAP  – Astrocytic activation in neuropathic pain

Iba1 (AIF1)  – Microglial sensitisation is a hallmark of chronic pain

Focus Biomolecules

Paired Targets (Plus Antibody)

Apomorphine HCl–

A dopamine pan-receptor agonist with anti-Parkinson’s activity

α-Synuclein  – Dopaminergic agonists are central in Parkinson’s disease models

Tyrosine Hydroxylase – Gold-standard dopaminergic neuron marker used with apomorphine studies

Kainic Acid (excitotoxicity inducer)–

Conformationally restricted glutamate analogue; selective agonist at kainate receptors

c-Fos  – Linked with excitotoxic neuronal activation (via PSD-95/NMDA pathways)

NMDA Receptor (NR1/NR2) – Standard markers for excitotoxicity models

Lysophosphatidic Acid (LPA, oleyl)–

A multifunctional bioactive phospholipid that stimulates growth in various cell types

Iba1 (AIF1) – LPA is a potent microglial activator

JNJ-3792165 (GPR139 antagonist) –

First to Market–

Potent and selective antagonist at GPR139, a non-canonical opioid receptor

Tyrosine Hydroxylase (TH)  – GPR139 regulates dopaminergic circuitry

BDNF  – GPR139 modulation affects BDNF-linked signalling in striatal circuits