Custom Cytogenetics Services
Services We Offer
2BScientific offers comprehensive custom cytogenetic services through myTags® platform, providing researchers with novel fluorescence in situ hybridisation (FISH) probes and expert support. Their synthetic oligonucleotide-based approach delivers superior performance across a range of applications, including chromosome painting, gene mapping, supporting research in animals, plants, and microbes. The services offered include:
Comprehensive Probe Design Services:
- Custom probe development for any genome reference sequence;
- Support for target regions from single loci to full chromosomes;
- Complimentary design consultation.
Flexible Synthesis Options:
- Single Synthesis: Individual probe set designs up to 108k unique sequences;
- Indexed Synthesis: Multiple probe sets (2-10 designs) per synthesis event.
Advanced Labelling Services:
- Ready-to-use labelled probes with multiple fluorophore options;
- Immortal amplifiable substrates for in-house labelling;
- Compatible with standard FISH protocols and oligopaints methods.
Chromosome Analysis and Visualisation:
- Multicolour FISH for chromosome identification;
- Chromosome painting and barcoding; 3D DNA-FISH for spatial chromosome organisation;
- Cryo-FISH for preserved sample analysis;
- Super-resolution compatible probes for detailed structural analysis.
Advanced Genomic Applications for gene mapping and expression analysis:
- Chromosomal rearrangement detection (translocations, duplications, deletions);
- Scaffold assembly with visual confirmation;
- Haplotyping analysis for meiotic crossover events;
- RNA-FISH for gene expression studies.
Key Benefits
Superior Performance and Specificity
- Higher accuracy than traditional methods:
- myTags® synthetic probes demonstrate higher specificity compared to genomic-derived probes, with targeted hybridisation only to intended loci while BAC-derived probes show multiple off-target hybridisations. This precision reduces experimental noise and improves data quality.
- Advanced resolution capabilities:
- myTags® probes enable super-resolution mapping of chromosomal spatial structures when combined with spatial super-resolution structured illumination microscopy (3D-SIM), allowing researchers to resolve complex chromatin arrangements and calculate chromatin compaction levels.
Easy Implementation
- Compatible with existing FISH protocols and equipment
- Multiple format options (immortal substrates or ready-to-use labelled probes)
- Optimised protocols available for new and experienced users
- Standard 3–4-week turnaround time
Faster Research Efficiency
- Reduced experimental setup time with ready-to-use options
- Streamlined ordering process with expert consultation
How to Enquire
- Fill in the custom cytogenetics services form below.
- Our Product Managers will setup a call or send an email to understand the scope of the project, specific project requirements and the desired outcome.
- Our Team might also need to arrange a Teams with the Manufacturer to collect more detailed information.
