Custom Oligonucleotide Synthesis Services

Services we offer 

• Standard DNA and RNA oligonucleotides
  - High-quality single-stranded DNA oligonucleotides tailored to your specifications which are  suitable for PCR, sequencing, cloning, and other molecular biology applications. Delivered with exceptional purity, they are available in a range of scales (from 200nmol up to 25umol).
  - We provide high-quality RNA oligonucleotides synthesized with or without chemical modifications. Choose from 2'-O-methylation, phosphorothioate bonds, or capped RNA for enhanced stability and specific experimental applications, including RNA interference (RNAi) and mRNA research.
• Large-Scale Oligonucleotide Production
  For applications requiring large quantities of oligonucleotides, we offer scalable synthesis solutions. We ensure consistent quality for research, diagnostic, or industrial purposes.
• Modified Oligonucleotides
  Whether you need increased stability, enhanced hybridization, or functional tags for downstream applications, we can tailor modifications to meet your experimental needs. These include Fluorescent Quencher Modifications , Backbone Modifications , Functional Conjugations , and other modifications like adding spacers, linkers etc.
• siRNA Synthesis
  Design and order small interfering RNAs (siRNAs) for gene silencing applications. We offer single or duplex RNA oligos, with optional chemical modifications, to maximize silencing efficiency and reduce off-target effects.

• Complex Oligonucleotides
  Design and order complex sequences, including challenging constructs such as hairpins, tandem repeats, or high GC-content regions. Our synthesis process ensures high fidelity even for difficult sequences.
• Chimeric oligonucleotides
  We offer custom synthesis of chimeric oligonucleotides, combining DNA, RNA, and modified nucleotides in a single synthesis. These hybrid oligonucleotides are ideal for applications such as gene editing, antisense therapy, and functional studies, enabling precise control over hybridization and stability. Each chimeric oligo is synthesized with high fidelity and can include a variety of modifications, tailored to your experimental needs.
• Clickable oligonucleotides
  Oligos containing azide/alkyne mo. As well as TCO groups for strain promoted click reactions.
• Probes for Molecular Diagnostics
  Accurate and reliable probe synthesis for molecular diagnostics applications, including dual-labeled probes, Each probe is synthesized and purified to meet the stringent requirements of diagnostic workflows.
• Locked Nucleic Acids (LNA)
  Locked nucleic acids (LNA) provide superior binding affinity and specificity in hybridization assays and oligonucleotide-based therapies. These chemically modified nucleotides are ideal for antisense application, diagnostic probes and SNP detection.

Key Benefits to the Customer 

• Offers the highest purity, quality, and yield at highly competitive prices.
• Their "team of experts" provides "personalized support" to help customers select the perfect modifications, this includes guidance on choosing appropriate dyes, quenchers, or any of their 500 modifications.
• Offers multiple synthesis scales (200 nmol, 1000 nmol, and 10,000 nmol) with large-scale production capabilities, making them suitable for both research and commercial applications.

What the Process involves 

• PMs will setup a call or send an email to understand the scope of the project, specific project requirements and the outcome customers require.
• Post discussion PMs will setup the requirements using the oligonucleotide calculator and provide the quotes to the customer.
• PMs can also arrange a Teams call with the technical team for further  project understanding and customisation.