Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized)
Product Sizes
100 ug
SPR-469-100UG
2 x 100 ug
SPR-469-2X100UG
5 x 100 ug
SPR-469-5X100UG
About this Product
- SKU:
- SPR-469
- Additional Names:
- Alpha-synuclein, Alpha synuclein, Asyn, SNCA, NACP, PARK1, PARK4, PD1, Synuclein alpha, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Synuclein Alpha-140, SYN, Parkinson's disease familial 1 Protein Protein
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Concentration:
- 2 mg/ml
- Extra Details:
- Alpha-synuclein, encoded by the SNCA gene (UniProt ID: P37840), is a presynaptic neuronal protein involved in synaptic vesicle trafficking and neurotransmitter release. Under pathological conditions, alpha-synuclein misfolds and assembles into soluble oligomers-intermediates in the formation of insoluble fibrils found in Lewy bodies, a hallmark of Parkinson's disease and related synucleinopathies. Alpha-synuclein oligomers are increasingly recognized as the most neurotoxic species in the aggregation cascade. These oligomers disrupt cellular homeostasis by compromising membrane integrity, impairing mitochondrial function, and interfering with protein degradation pathways. Their ability to propagate between neurons in a prion-like fashion contributes to the progressive spread of neurodegeneration. Experimental models using alpha-synuclein oligomers have revealed their role in triggering neuroinflammation, synaptic dysfunction, and selective neuronal loss. These insights have positioned oligomers as critical targets for therapeutic intervention and biomarker development. Epigallocatechin Gallate (EGCG) reduces alpha synuclein fibril formation in favour of spherical soluble oligomers. Due to their structural and functional relevance to human disease, alpha-synuclein oligomers are widely used in preclinical research to evaluate aggregation inhibitors, immunotherapies, and neuroprotective agents. Their application enhances the translational potential of drug discovery efforts aimed at halting or reversing neurodegenerative progression.
- Immunogen:
- Alpha Synuclein Oligomers
- Molecular Weight:
- ~14.46 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/alpha-synuclein-protein-spr-469/
