Alpha Synuclein Pre-formed Fibrils: ATTO 594 (Type 1)
Product Sizes
100 ug
SPR-322-A594-100UG
2 x 100 ug
SPR-322-A594-2X100UG
5 x 100 ug
SPR-322-A594-5X100UG
About this Product
- SKU:
- SPR-322-A594
- Additional Names:
- Alpha-synuclein, Alpha synuclein, Asyn, SNCA, NACP, PARK1, PARK4, PD1, Synuclein alpha, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Synuclein Alpha-140, SYN, Parkinson's disease familial 1 Protein Protein, Alpha Synuclein PFFs, ATTO labelled Alpha Synuclein fibrils
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS pH7.4, 0.09% Azide
- CE/IVD:
- RUO
- Conjugate:
- ATTO 594
- Extra Details:
- Alpha-synuclein (A Alpha-syn), a neuronal protein encoded by the SNCA gene, plays a critical role in synaptic function, including vesicle trafficking and neurotransmitter release. Under physiological conditions, A Alpha-syn exists primarily in monomeric or tetrameric forms. However, pathological misfolding of A Alpha-syn can lead to the formation of pre-formed fibrils (PFFs), which are central to the progression of synucleinopathies such as Parkinson's disease, Lewy body dementia, and multiple system atrophy. PFFs are structurally stable aggregates that act as seeds for the recruitment and conversion of native A Alpha-syn into toxic fibrillar forms. This seeding mechanism initiates a prion-like spread of misfolded A Alpha-syn across neuronal networks, leading to the accumulation of Lewy bodies and neurites-hallmarks of neurodegenerative pathology. The presence of PFFs disrupts cellular homeostasis, impairs mitochondrial function, and activates neuroinflammatory responses, contributing to progressive neuronal dysfunction and death. Experimental models utilizing A Alpha-syn PFFs have demonstrated their capacity to replicate disease-like features, including synaptic deficits, motor impairments, and widespread protein aggregation. These models are instrumental in elucidating disease mechanisms and identifying therapeutic targets. Targeting the formation, propagation, or cellular uptake of A Alpha-syn PFFs represents a promising strategy for disease modification. Advances in understanding the molecular behavior of PFFs are paving the way for novel interventions aimed at halting or reversing neurodegenerative processes.
- Immunogen:
- Alpha Synuclein PFFs
- Purity:
- >95%
- Purification:
- Ion Exchange
- Sequence:
- MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/alpha-synuclein-protein-spr-322-A594/
