Host Cell Protein Products from ICL

ICL ELISA Kits

ICL was among the first to commercialize ELISA kits that use highly specific and sensitive antibodies developed in our lab to detect specific CHO host cell proteins (HCP) like PLBL2 and NUCB2. HCP may co-purify and contaminate monoclonal antibodies cultured in CHO cells, but ELISA kits make it fast and simple to identify these variables before they affect your research. Reducing or minimizing HCP impurities is mandated by federal guidelines and is crucial in the development and manufacturing of recombinant biotherapeutics, which are key treatment options for a wide range of illnesses.

Reducing CHO Protein Impurities 

Many approved therapeutic glycoproteins are manufactured in Chinese Hamster Ovary (CHO) cells. While CHO cells are one of the most genetically engineered host cell systems for recombinant protein production, the contamination of CHO host cell proteins can adversely affect their use. Without addressing HCP impurities, there is an increased risk of contaminating research and even triggering an immune response upon administration. 3.000 2.500 2.000 1.500 ICL's high-quality antibodies and ELISA kits target specific CHO cells to avoid compromising patient safety and ensure more desirable clinical outcomes. Conducting a comprehensive risk assessment of host cell protein levels in CHO cell-based protein production is essential, and research or IVD teams can easily mitigate those risks by using a reliable, trusted supplier of biological reagents.