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Anti-BDCA-2 (CD303)

CD303 is a calcium dependent type II lectin also known as Blood-Dendritic-Cell-Antigen-2 specifically expressed by human plasmacytoid dendritic cells (pDC). CD303/BDCA-2 is a 25 kDa type II membrane glycoprotein with a single carbohydrate recognition domain (CRD) predicting mannose-type specificity. Protein expression is restricted to the immature plasmacytoïd dendritic cells subset. BDCA-2 is involved in ligand internalization, processing and presentation, as well as in inhibition of IFN-α/ß synthesis.

(Treilleux I. et al, 2004, Clin. Canc. Res., 10: 7466; Dzionek A. et al, 2000, J. Immunol., 165, 6037; Dzionek A. et al, 2001 J. Exp. Med. 194, 1823-1834)

Features

  • Monoclonal (different clones available)
  • Various applications (IHC paraffin, IHC frozen, IF, Cytometry…)
  • 5 different conjugates(Alexa, Biotin, HRPO…)

Characteristics

Producing speciesMouse
SpecificityHuman CD303
Immunogenrecombinant human BDCA2-like protein
PurificationQMA Hyper D ion exchange chromatography
Clone124B3.13
IsotypeIGg1
Frozen section+++
Paraffin section+++
NomenclatureFlow cytometryBiological effectsImmunohistochemistry
RéférenceCloneIsotypeCOP5- CD303 surface proteinCOP5- CD303  intracytoMonoDC GMCSF-IL-4 intracytoMonoDC GMCSF-IL-4 surfaceInhibits IFN αIncrease IFN αApoptosisFrozen sectionParaffin section
DDX0040108h10.03IgM++++++-+++-+++++++
DDX0041104C12.08IGg1+++-+/----+++++
DDX0042110H7.05IGg1+++++++++++++-+++++++
DDX0043124B3.13IGg1+/-+++-+/----++++++

These different clones represent powerful tools contributing to a better understanding of human pathophysiology related to PDCs.

CONJUGATE

Availablefor eachclone

PURIFIEDBIOTINHRPOALEXA 488ALEXA 546ALEXA 647

To get a quote for the products or to place an order, please email Sales@2BScientific.com