EV Isolation from Biopsy

Extracellular Vesicles (EV) are a heterogenous population of membranous vesicles secreted by the cells into the extracellular millue. They act as cell mediators carrying messenger components like nucleic acids (RNA, microRNA, DNA), lipids, cellular proteins that can influence the behaviour of recipient cells. Source of EVs are abundant in biofluids.

Mounting evidence suggests that alterations in the quantity and composition of EVs contribute to the remodelling of the immune-suppressive tumour microenvironment (TME), thereby influencing the efficacy of immunotherapy. This revelation has sparked clinical interest in utilising EVs for immune sensitisation. EV research is largely being focused on biomarker development and therapeutic agents for cancer immunotherapy, however greater insight is required to understand EV characterisation in different cell types and in cancer cells.

2BScientific Limited prides themselves in staying abreast with new research studies  and selects leading suppliers that can offer new innovations to advance these studies. EV research has seen considerable focus in cancer biology with future predictions for them to become therapeutic biomarkers and drug delivery agents in targeted cancer cells. With current challenges with efficient EV isolation from Liquid Biopsy and other biofluids, further insight on EV subsets becomes difficult. Therefore, 2BScientific has collected the best of the best suppliers with EV expertise to offer easy to use kits, faster enrichment and purification methods for the EVs with their innovative tools and products.