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Assay Kits & ELISAs

DNA Damage (8-OHdG) ELISA Kit

Product Sizes
1 kit
KOA0887-1KIT
About this Product
SKU:
KOA0887
Additional Names:
8-OH-dG ELISA Kit, 8OHG ELISA Kit, 80G ELISA Kit, 8 hydroxyguanine ELISA Kit, DNA Damage ELISA Kit, 8OHdG ELISA Kit, 8-ohdg ELISA Kit, DNA Damage Enzyme-Linked Immunosorbent Assay, 8-OHdG ELISA Kit
Application:
ELISA
CE/IVD:
RUO
Clonality:
Monoclonal
Conjugate:
HRP
Extra Details:
8-hydroxy-2-deoxy Guanosine (8-OHdG) is produced by the oxidative damage of DNA by reactive oxygen and nitrogen species and serves as an established marker of oxidative stress. Hydroxylation of guanosine occurs in response to both normal metabolic processes and a variety of environmental factors (i.e., anything that increases reactive oxygen and nitrogen species). Increased levels of 8-OHdG are associated with the aging process as well as with a number of pathological conditions including cancer, diabetes, and hypertension. In complex samples such as plasma, cell lysates, and tissues, 8-OHdG can exist as either the free nucleoside or incorporated in DNA. Once the blood enters the kidney, free 8-OHdG is readily filtered into the urine, while larger DNA fragments remain in the bloodstream. Because of the complexity of plasma samples, urine is a more suitable matrix for the measurement of free 8-OHdG than plasma. Urinary levels of 8-OHdG range between 2.7-13 ng/mg creatine, while plasma levels of free 8-OHdG have been reported to be between 4-21 pg/ml as determined by LC-MS.
Range:
0.94 ng/ml - 60 ng/ml
Reactivities:
Wide/Non-species Specific
Sensitivity:
0.59 ng/ml
Shipping Conditions:
Blue Ice
Specificity:
This kit contains: 96 wells coated plate, Target Protein Standard, HRP Conjugated Monoclonal Antibody, Diluent, Wash buffer, TMB Substrate and stop reagent, see protocol for additional information.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Assay Kits: ELISAs
ELISA results of DNA Damage (8-OHdG) displaying a typical Standard Curve for this kit using competitive/colorimetric ELISA Assay. Assay range 0.94-60ng/mL.