Human Seprase - FAP ELISA Kit
Product Sizes
1 kit
£738.00
KOA0627-1KIT
About this Product
- SKU:
- KOA0627
- Additional Names:
- 170 kDa melanoma membrane-bound gelatinase, FAP, Fibroblast activation protein alpha, Integral membrane serine protease, SEPR_HUMAN, Seprase|FAP
- Application:
- ELISA
- CE/IVD:
- RUO
- Extra Details:
- FAP(Fibroblast Activation Protein, Alpha) also known as FAPA or SEPRASE, is an inducible cell surface glycoprotein that was originally identified in cultured fibroblasts using monoclonal antibody F19. The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. The FAP gene is mapped on 2q24.2. FAP is most closely related to DPPIV and they share about 50% of their amino acids. FAP is catalytically active as a 170kD dimer and has dipeptidase and gelatinase activity. Its gelatinase activity requires a glycine in P2 position. FAP-alpha shows 48% amino acid identity with dipeptidyl peptidase IV and 30% identity with DPP4-related protein. Northern blot analysis detected a 2.8-kb FAP-alpha mRNA in fibroblasts. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-gamma and tumor necrosis factor-alpha.
- Immunogen:
- Expression system for standard: NSO; Immunogen sequence: L26-D760
- Range:
- 62.5 pg/ml - 4000 pg/ml
- Reactivities:
- Human
- Sensitivity:
- <10 pg/ml
- Shipping Conditions:
- Blue Ice
- Specificity:
- Natural and recombinant human Seprase. There is no detectable cross-reactivity with other relevant proteins.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=KOA0627
