TLR4 Antibody
Product Sizes
25 ul
600-401-MK3S-25UL
About this Product
- SKU:
- 600-401-MK3S
- Additional Names:
- Rabbit Anti-TLR4 Antibody, ARMD10 antibody, CD284 antibody, Toll (Drosophila) homolog antibody, HToll, Homolog of Drosophila Toll, TLR-4 Antibody, TOLL antibody, Toll Endotoxin Hyporesponsiveness antibody, Toll like receptor 4 antibody, Toll like receptor 4 precursor antibody|TLR4
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- TLR4 (Toll-Like Receptor 4). Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis. Mutations in this gene have been associated with differences in LPS responsiveness, macular degeneration, and pertussis. Anti-TLR4 Antibody is useful for researchers interested in transcription factor research, cytokine research, MIF action through Endocytic Pathway, and rheumatoid arthritis.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Rabbit
- Immunogen:
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the n-terminus of human TLR4 protein.
- Isotype:
- IgG
- Physical State:
- Liquid
- Reactivities:
- Human
- Shipping Conditions:
- Dry Ice
- Specificity:
- This affinity purified antibody is directed against human TLR4 protein. The product was purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest reactivity with TLR4 protein from human based on 100% homology with the immunizing sequence. The analysis also shows 100% cross-reactivity with gorilla and bonobo, and canine species.
- Storage Conditions:
- -20[o]C diluted. Avoid freeze/thaw cycles., See Manual Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=600-401-MK3S
