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Antibodies

NALP7 Antibody

Product Sizes
100 ug
£608.00
600-401-CY5-100UG
About this Product
SKU:
600-401-CY5
Additional Names:
NALP7 Antibody, HYDM, PAN7, NALP7, NOD12, PYPAF3, CLR19.4, NACHT, LRR and PYD domains-containing protein 7, Nucleotide-binding oligomerization domain protein 12|NLRP7
Application:
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Buffer:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
CE/IVD:
RUO
Clonality:
Polyclonal
Concentration:
1 mg/ml
Extra Details:
NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1b secretion and is a feedback regulator of interleukin-1b secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
Formulation:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Host:
Rabbit
Immunogen:
Anti-NALP7 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the N-terminus of human NALP7.
Isotype:
IgG
Physical State:
Liquid
Reactivities:
Human
Shipping Conditions:
Blue Ice
Specificity:
Anti-NALP7 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with NALP7 from other sources has not been determined.
Storage Conditions:
2-8[o]C
Supplier:
Rockland Inc
Type:
Antibody: Polyclonal Antibody
Western Blot of NALP7 antibody. Lane 1: human brain tissue lysate with NALP7 antibody at 1 ug/mL in the absence of blocking peptide. Lane 2: human brain tissue lysate with NALP7 antibody at 1 ug/mL in the presence of blocking peptide. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 112 kDa, 130 kDa for NALP7. Other band(s): NALP7 splice variants and isoforms.
Immunohistochemistry of NALP7 antibody. Tissue: Human brain tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: NALP7 antibody at 10 ug/mL for 1 h at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: NALP7 as precipitated pink signal with brown nuclear counterstain.
Immunofluorescence Microscopy of NALP7 antibody. Tissue: Human brain tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: NALP7 antibody at 20 ug/mL for 1 h at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: NALP7 as red fluorescent signal.