Recombinant Anti-CD20 Fab Antibody
Product Sizes
50 ug
£543.00
400-001-MT2-50UG
About this Product
- SKU:
- 400-001-MT2
- Additional Names:
- Membrane Spanning 4-Domains A1, Recombinant Monoclonal CD20, RabMab CD20, Bp35, Membrane-Spanning 4-Domains, Subfamily A, Member 1, Leukocyte Surface Antigen Leu-16, B-Lymphocyte Antigen CD20, CD20 Antigen, MS4A2, CD20, B1, Membrane-Spanning 4-Domains Subfamily A Member 1, B-Lymphocyte Cell-Surface Antigen B1, B-Lymphocyte Surface Antigen B1, CD20 Receptor, LEU-16, CVID5, MS4A1, S7, Rituximab, Rituxan|MS4A1
- Application:
- ELISA, Flow Cytometry, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- Abz522
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 0.36 mg/ml
- Extra Details:
- CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82. Anti-CD20 antibody, Rituximab, sold under the brand name Rituxan, is a medication used to treat certain autoimmune diseases and types of cancer. It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in non-geriatric patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura, pemphigus vulgaris, myasthenia gravis and Epstein-Barr virus-positive mucocutaneous ulcers. Biosimilars of Rituxan include Blitzima, Riabni, Ritemvia, Rituenza (F.K.A. Tuxella), Rixathon, Ruxience, and Truxima. This antibody is made from a Rituximab Fab fragment making it specific, efficient, and effective. Recombinant Anti-CD20 Fab fragment Antibody is useful for researchers interested in autoimmune disease and cancer research.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Human
- Immunogen:
- MS4A1
- Isotype:
- IgG, IgG1
- Physical State:
- Liquid
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Humanized Recombinant CD20 Fab fragment was expressed in HEK293 cells. Purified by one-step purification by HisTrap FF Crude. The purity was estimated to be >95% by SDS-PAGE analysis.
- Storage Conditions:
- -20[o]C
- Supplier:
- Rockland Inc
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=400-001-MT2
