Ubiquitin Hydrolase (UCHL1) Antibody
Product Sizes
100 ul
£627.00
200-901-E52-100UL
About this Product
- SKU:
- 200-901-E52
- Additional Names:
- UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Ubiquitin thioesterase L1|UCHL1
- Application:
- Detection/Quantitation, ELISA, Immunofluorescence, Western Blot
- Buffer:
- 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Extra Details:
- UCHL1 antibody recognizes Ubiquitin C-terminal hydrolase 1 (UCHL1) which is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker. Therefore, UCHL1 antibody is ideal for investigators involved in neuronal disorders and, more generally in Neuroscience.
- Formulation:
- 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Chicken/Avian
- Immunogen:
- Anti-UCHL1 Antibody was produced in chicken by repeated immunizations with recombinant full length human UCHL1 extensively purified from E. coli.
- Isotype:
- IgY
- Physical State:
- Liquid
- Reactivities:
- Bovine, Human, Mouse, Rat
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-UCHL1 antibody is directed against human UCHL1 proteins. The antibody was purified from chicken eggs as an IgY fraction. Reactivity is expected from human, mouse, rat and bovine. Cross reactivity with UCHL1 from other species has not been determined. However, expect reactivity against most mammalian species based on high sequence homology.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-901-E52
