ECRG2 Antibody
Product Sizes
100 ug
£683.00
200-901-AY8-100UG
About this Product
- SKU:
- 200-901-AY8
- Additional Names:
- ECRG2 Antibody, ECG2, ECRG2, ECG2, UNQ745/PRO1474, Serine protease inhibitor Kazal-type 7, Esophagus cancer-related gene 2 protein, ECRG-2|SPINK7
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Host:
- Chicken/Avian
- Immunogen:
- Anti-ECRG2 antibody was prepared from chicken egg fractions produced by repeated immunizations with a 16 amino acid synthetic peptide near the C-terminus of human ECRG2.
- Isotype:
- IgY
- Physical State:
- Liquid
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-ECRG2 Antibody is an IgY fraction that has been affinity purified by immunoaffinity purification. ECRG2 antibody is predicted to not cross-react with other ECRG family members
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-901-AY8
