CD8a Fluorescein Antibody
Product Sizes
100 ug
£175.00
200-502-N78-100UG
About this Product
- SKU:
- 200-502-N78
- Additional Names:
- Cd8a|T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2
- Application:
- Flow Cytometry, Immunohistochemistry
- Buffer:
- 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 2.43
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Concentration:
- 0.5 mg/ml
- Extra Details:
- CD8a antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites. The 2.43 antibody is widely used as a phenotypic marker for mouse CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.
- Formulation:
- 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Rat
- Immunogen:
- Anti-CD8a Antibody (Monoclonal) was produced by repeated immunizations with CD8a antigen.
- Isotype:
- IgG2b, IgG2b, kappa
- Physical State:
- Liquid
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- Fluorescein conjugated CD8a Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against mouse CD8a. Cross reactivity with CD8a from other sources has not been tested. Anti-CD8a is conjugated with FITC under optimal conditions and the solution is free of unconjugated FITC.
- Storage Conditions:
- 2-8[o]C diluted. Do not freeze. Protect from light.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- FluoroFinder:
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-502-N78
