Beta-Site App-Cleaving Enzyme Antibody
Product Sizes
100 ug
£683.00
200-401-984-100UG
About this Product
- SKU:
- 200-401-984
- Additional Names:
- APP beta secretase antibody, Asp 2 antibody, ASP2 antibody, Aspartyl protease 2 antibody, BACE 1 antibody, BACE antibody, Beta secretase 1 antibody, Beta secretase antibody, Membrane-Associated Aspartic Protease 2, Beta-Site APP Cleaving Enzyme 1, Memapsin-2, Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme, Transmembrane Aspartic Proteinase Asp2|BACE1
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. Anti-BACE antibody is ideal for investigators involved in Neuroscience research.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Rabbit
- Immunogen:
- BACE Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of human BACE protein.
- Isotype:
- IgG
- Physical State:
- Liquid
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-BACE Antibody is directed against human BACE protein. The product is affinity chromatography purified via peptide column. The antibody is human and mouse reactive. Reactivity against homologues from other sources has not been determined.
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-401-984
