CD4 Allophycocyanin Antibody
Product Sizes
500 ul
£175.00
200-326-N18-500UL
About this Product
- SKU:
- 200-326-N18
- Additional Names:
- CD4|T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, FITC anti-human CD4, RPA-T4, APC, T4
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- OKT4
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Concentration:
- 0.025 mg/ml
- Extra Details:
- The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The OKT4 antibody is widely used as a phenotypic marker for CD4 expression.
- Formulation:
- 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Mouse
- Immunogen:
- Anti-CD4 Antibody (Monoclonal) was produced by repeated immunizations with CD4 antigen.
- Isotype:
- IgG2b, IgG2b, kappa
- Physical State:
- Liquid
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Allophycocyanin conjugated CD4 Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD4. Reactivity is observed against human CD4, Cynomolgus, Rhesus, and chimpanzee. This antibody recognizes a different epitope, and thus does not block binding of clone RPA-T4. Cross reactivity with CD4 from other sources has not been tested. An
- Storage Conditions:
- 2-8[o]C unopened. Protect from light.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- FluoroFinder:
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-326-N18
