MITF Antibody
Product Sizes
100 ug
£679.00
200-301-H93-100UG
About this Product
- SKU:
- 200-301-H93
- Additional Names:
- BHLHE32, Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32|MITF
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 21D1418
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Anti-MITF antibody detects human MITF. Microphthalmia-associated bHLH-LZ transcription factor (MITF) is a positively acting transcription factor containing a transcription activation domain and a bHLH-LZ domain that mediates DNA-binding and dimerization. Both the transcription activation and bHLH-LZ domains are highly conserved in the closely related TFE3, TFEB and TFEC. MITF can form heterodimers in vitro with the above transcription factors, but not with other bHLH-LZ factors such as Myc, Max or USF. MITF is expressed as multiple isoforms, which share common activation and DNA-binding domains, but differ in the amino-terminal region. MITF is targeted by three kinases: GSK-3beta, Map kinase ERK2 and members of the p90 Rsk family of kinases. Anti-MITF antibody is ideal for investigators involved in kinase, phosphatase, NFkappaB, and signaling research.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Mouse
- Immunogen:
- MITF Antibody was produced in mice prepared by repeated immunizations with a synthetic peptide (sequence PSTGLCSPDLVN) corresponding to internal amino acids with human MITF protein.
- Isotype:
- IgG1
- Physical State:
- Liquid
- Reactivities:
- Human
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-MITF Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with MITF from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-MITF from other sources has not been determined.
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-301-H93
