CaMKII Antibody
Product Sizes
100 ug
£614.00
200-301-F01-100UG
About this Product
- SKU:
- 200-301-F01
- Additional Names:
- CamK2, CamK2A, CamK2B, CamK2D, CamK2G, CAMKA, Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha|Camk2a
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 22B1
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CaMKII is an important member of calcium/calmodulin- activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling. CaMKII is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consist of two subunits of 52 (termed alpha genes) and 60 kDa (beta genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site. The binding of Ca2+ auto inhibitory effect and activates the kinase . This kinase activation results in autophosphorylation at threonine 286. The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. Whereas PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286, PKA (protein kinase A) prevents this dephosphorylation. Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Mouse
- Immunogen:
- CaMKII Antibody was produced in mice by repeated immunizations with synthetic peptide of rat CaMKII.
- Isotype:
- IgG1
- Physical State:
- Liquid
- Reactivities:
- Rat
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-CaMKII Antibody was purified by Protein G chromatography. This monoclonal antibody is specific for CaMKII protein. A BLAST analysis was used to suggest cross-reactivity with CaMKII from rat based on 100% homology with the immunizing sequence. Cross-reactivity with CaMKII from other sources has not been determined. Cell Signaling research.
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-301-F01
