BUB1 Antibody
Product Sizes
100 ug
200-301-900-100UG
About this Product
- SKU:
- 200-301-900
- Additional Names:
- BUB1|mouse anti-BUB1 antibody, Budding uninhibited by benzimidazoles 1 homolog antibody, hBUB1 antibody, Mitotic checkpoint serine/threonine protein kinase BUB1 antibody
- Application:
- ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 14H5
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- BUB1 (also called Mitotic checkpoint serine/threonine-protein kinase BUB1and BUB1A) is a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating BUB3, a member of the miotic checkpoint complex, and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. BUB1 is autophosphorylated when cells enter mitosis. This protein is localized to the nucleus in interphase cells. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage. BUB1 is highly expressed in testis and thymus, less in colon, spleen, lung and small intestine. Expression is associated with cells/tissues with a high mitotic index.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Mouse
- Immunogen:
- This protein A purified monoclonal antibody was produced by repeated immunizations with a recombinant protein corresponding to amino acid residues 281-419 of human BUB1 protein.
- Isotype:
- IgG1
- Physical State:
- Liquid
- Reactivities:
- Human
- Shipping Conditions:
- Dry Ice
- Specificity:
- This Protein A purified antibody is directed against human BUB1 protein. The product was purified from tissue culture supernatant by chromatography. This antibody reacts with BUB1 from human cells. No reactivity is seen for homologues from Xenopus or Kangaroo Rat. Reactivity against homologues from other sources is not known.
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-301-900