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Proteins and Peptides

rRat MIP-1 alpha (CCL3) Protein

Product Sizes
100 ug
£680.00
012-001-V80-0100-100UG
About this Product
SKU:
012-001-V80-0100
Additional Names:
Ccl3|LD78A Alpha, Macrophage inflammatory protein 1-alpha (MIP-1-alpha)
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Macrophage Inflammatory Protein-1 alpha (MIP-1A Alpha), also known as CCL3, is produced by macrophages and is thought to induce inflammatory responses, including superoxide production by neutrophils. MIP-1A Alpha can exist as a naturally occurring heterodimer with MIP-1B Beta and has been shown to have antiviral activity against HSV-1. Recombinant rat MIP-1A Alpha is a non-glycosylated protein, containing 69 amino acids, with a molecular weight of 7.8 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
Ccl3
Physical State:
Lyophilized
Purity:
>95%
Shipping Conditions:
Ambient
Specificity:
Macrophage Inflammatory protein-1 alpha (CCL3) purity was determined to be greater than 95% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Rat Macrophage Inflammatory Protein-1 alpha (CCL3) Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 ug Rat MIP-1 in non-reducing conditions (-). Lane 3: 1 ug Rat MIP-1 in reducing conditions (+). Rat MIP-1 alpha has a predicted MW of 7.8 kDa.
Bioactivity of Rat Macrophage Inflammatory Protein-1 alpha (CCL3) Recombinant Protein. Human PBMCs were allowed to migrate to Rat MIP-1 alpha at (0, 0.19, 0.78, 3.1, 12.5 and 200 ng/mL). After 4 hours, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Rat MIP-1 alpha starting at 10 ng/mL. This value is comparable to expected ranges of a chemotactic response of primary human monocytes.