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Antibodies

Low Endotoxin Control Rabbit IgG

Product Sizes
500 ug
£229.00
011-001-297-500UG
About this Product
SKU:
011-001-297
Additional Names:
Rabbit immunoglobulin G, Low EU Immunoglobulin control, Low EU standard
Application:
ELISA, Immunohistochemistry, Western Blot
Buffer:
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
CE/IVD:
RUO
Concentration:
1 mg/ml
Extra Details:
Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75% of serum immunoglobulins. Immunoglobulin G binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsonization for phagocytosis. The whole IgG molecule possesses both the F(c) region, recognized by high-affinity Fc receptor proteins, as well as the F(ab) region possessing the epitope-recognition site. Both heavy and light chains of the antibody molecule are present.
Formulation:
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Physical State:
Liquid
Shipping Conditions:
Dry Ice
Specificity:
Low Endotoxin Control Rabbit IgG is an IgG preparation of whole rabbit serum purified by protein A chromatography using a low endotoxin methodology.
Storage Conditions:
-20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:
Rockland Inc
Type:
Antibody: Isotype Controls
Negative controls of neutralization assay. Low endotoxin isotype control Abs were added (goat IgG, 100 ug/ml; rabbit IgG, 2 ug/ml; mouse IgG, 1 ug/ml) to the 10% PRP supplemented media as controls. No significant changes in proliferation were noticed when adding the isotype control Abs to the PRP supplemented hMDPC cultures compare to the PRP groups (n = 4). Low Endotoxin Control Rabbit IgG (p/n 011-001-297). Figure S1. PMID: 23762264.
Changes of body temperature (°C) over time (h) of rats treated intraperitoneally at 7:00 with TNF-A Alpha antibodies (50 ug/rat i.p.) and at 8:00 with AUDA in a dose of 15 mg/kg an hour before LPS (50 ug/kg i.p.) (open circles) or NaCl (open squares) administration. Closed triangles represent Tb of rats treated at 7:00 with IgG (50 ug/rat i.p.) and at 8:00 with AUDA an hour before LPS injection (both in same concentration as above). Closed circles represent normal circadian rhythm of body temperature in non-treated rats. Sample size is indicated in parentheses. Black arrowheads represent the time of injection. Values are means +/- SEM at 30-min averages. Asterisks indicate significant difference (***p < 0.001) between experimental groups "TNFab/AUDA/LPS" and "IgG/AUDA/LPS". Low Endotoxin Control Rabbit IgG (p/n 011-001-297). Fig. 6. PMID: 28741242.