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Proteins and Peptides

rMouse CCL7 Protein

Product Sizes
10 ug
£319.00
010-001-V76-0010-10UG
About this Product
SKU:
010-001-V76-0010
Additional Names:
Ccl7|Intercrine/chemokine MARC, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3 (MCP-3), Protein FIC, Small-inducible cytokine A7
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Monocyte Chemotactic Protein 3 (MCP-3), also called CCL7, is produced by macrophages and some tumor cell lines. MCP-3 signals through three different G protein-coupled receptors, CCR1, CCR2, and CCR3. CCL7 chemoattracts monocytes and can regulate macrophage function. Recombinant mouse MCP-3 is a non-glycosylated protein, containing 74 amino acids, with a molecular weight of 8.5 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
Ccl7
Physical State:
Lyophilized
Purity:
>98%
Shipping Conditions:
Ambient
Specificity:
Monocyte Chemotactic protein-3 (CCL7) purity was determined to be greater than 98% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Mouse Monocyte Chemotactic Protein-3 (CCL7) Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 ug Mouse MCP-3 in non-reducing conditions (-). Lane 3: 1 ug Mouse MCP-3 in reducing conditions (+). Mouse MCP-3 has a predicted MW of 8.5 kDa.
Bioactivity of Mouse Monocyte Chemotactic Protein-3 (CCL7) Recombinant Protein. Human THP-1 cells were allowed to migrate to Mouse MCP-3 at (0, 0.1, 1, 10, 100 and 1000 ng/mL). After 45 minutes, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Mouse MCP-3 starting at 1000 ng/mL. This value is comparable to expected ranges of a chemotactic response of primary human monocytes.