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Proteins and Peptides

rMouse CCL8 Protein

Product Sizes
5 ug
£184.00
010-001-V75-0005-5UG
About this Product
SKU:
010-001-V75-0005
Additional Names:
Ccl8|HC14, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2 (MCP-2), Small-inducible cytokine A8
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Monocyte Chemotactic protein 2 (MCP-2), also known as CCL8, is implicated in allergic responses through its ability to activate mast cells, eosinophils, and basophils. MCP-2 is known to signal through several G protein-coupled receptors including, CCR1, CCR2B, and CCR5. Recombinant mouse MCP-2 is a non-glycosylated protein, containing 74 amino acids, with a molecular weight of 8.5 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
Ccl8
Physical State:
Lyophilized
Purity:
>98%
Shipping Conditions:
Ambient
Specificity:
Monocyte Chemotactic protein-2 (CCL8) purity was determined to be greater than 98% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Mouse Monocyte Chemotactic Protein-2 (CCL8) Recombinant Protein. Lane 1: 1 ug Mouse MCP-2 in non-reducing conditions (-). Lane 2: 1 ug Mouse MCP-2 in reducing conditions (+). Lane 3: Molecular weight marker. Mouse MCP-2 has a predicted MW of 8.5 kDa.
Bioactivity of Mouse Monocyte Chemotactic Protein-2 (CCL8) Recombinant Protein. Human THP-1 cells were allowed to migrate to Mouse MCP-2 at (0, 0.1, 1, and 10ng/mL). After 45 minutes, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Mouse MCP-2 starting at 1 ng/mL. This value is comparable to expected ranges of a chemotactic response of primary human monocytes.