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Proteins and Peptides

rMouse IP-10 (CXCL10) Protein

Product Sizes
100 ug
£680.00
010-001-V69-0100-100UG
About this Product
SKU:
010-001-V69-0100
Additional Names:
10 kDa interferon gamma-induced protein (IP-10), C7, Interferon-gamma induced protein CRG-2, small-inducible cytokine B10|Cxcl10
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Concentration:
0.1 mg/ml
Extra Details:
The chemokine IP-10 (or CXCL10) is a chemokine made by monocytes, endothelial cells and fibroblasts in response to treatment with IFNG Gamma. IP-10 functions as a chemoattractant to cells expressing the G protein-coupled receptor, CXCR3, which is found mainly on activated T cells and NK cells. IP-10 plays an important role in Th1 type inflammatory diseases and autoimmune diseases such as, Hashimoto's thyroiditis, Graves' disease and Type 1 diabetes mellitus. Recombinant mouse IP-10 is a non-glycosylated protein, containing 77 amino acids, with a molecular weight of 8.7 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
Cxcl10
Physical State:
Lyophilized
Purity:
>97%
Shipping Conditions:
Ambient
Specificity:
Ip-10 (CXCL10) purity was determined to be greater than 97% as determined by HpLC and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Mouse IP-10 (CXCL10) Recombinant Protein. Lane 1: 1 ug Mouse IP-10 in non-reducing conditions (-). Lane 2: 1 ug Mouse IP-10 in reducing conditions (+). Lane 3: Molecular weight marker. Mouse IP-10 has a predicted MW of 8.7 kDa.
Bioactivity of Mouse IP-10 (CXCL10) Recombinant Protein. Human T cells were allowed to migrate to Mouse IP-10 at (0, 5, 20, 100 and 500 ng/mL). After 4 hours, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Mouse IP-10 detectable starting at 5 ng/mL.