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Proteins and Peptides

rMouse IL-21 Protein

Product Sizes
100 ug
£1049.00
010-001-V61-0100-100UG
About this Product
SKU:
010-001-V61-0100
Additional Names:
Il21|Interleukin-21, IL-21, Za11, Interleukin 23
Application:
Cell-based/Functional Assay
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
Interleukin-21 (IL-21) is a member of the common gamma-chain family of cytokines (includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15) and is expressed by activated CD4+ T cells. IL-21 has a private receptor known as IL-21R, which is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells. Recombinant mouse IL-21 is a non-glycosylated protein, containing 130 amino acids, with a total molecular weight of 15.1 kDa.
Immunogen:
Il21
Physical State:
Lyophilized
Purity:
>95%
Shipping Conditions:
Ambient
Specificity:
Interleukin-21 purity was determined to be greater than 95% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Bioactivity of Mouse Interleukin-21 Recombinant Protein. Serial dilutions of Mouse IL-21 (starting at 100 ng/mL) or ConA (+ control) were added to primary mouse thymocytes cultured on an anti-cD3e coated plate. After 72 hours, total live thymoctyes were measured and the linear portion of the curve was us used to calculate the ED50. The ED50 of Mouse IL-21 is between 2.5-7.5 ng/mL. This effect is comparable to the competitor sample assayed in J. Parrish-Novak, et al. (2000) Nature 408:57-63.