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Proteins and Peptides

rMouse Follistatin Protein

Product Sizes
5 ug
£184.00
010-001-U88-0005-5UG
About this Product
SKU:
010-001-U88-0005
Additional Names:
FS, activin-binding protein, FSH-suppressing protein (FSP)|Fst
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide variety of TGF-beta family members (activin, BMPs, myostatin, GDF-11 and TGF-beta 1). Mechanistically, follistatin works as an antagonist by complexing with TGF-beta family members to prevent them from interacting with their signaling receptors. Recombinant mouse follistatin is a non-glycosylated protein, containing 289 amino acids, with a molecular weight of 31.6 kDa.
Immunogen:
Fst
Physical State:
Lyophilized
Purity:
>90%
Shipping Conditions:
Ambient
Specificity:
Follistatin purity was determined to be greater than 90% as determined by analysis by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Mouse Follistatin Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 ug Mouse Follistatin in non-reducing conditions (-). Lane 3: Molecular weight marker. Lane 4: 1 ug Mouse Follistatin in reducing conditions (+). Mouse Follistatin has a predicted MW of 31.6 kDa.
Bioactivity of Mouse Follistatin Recombinant Protein. Serial dilutions of Mouse Follistatin (starting at 1 ug/mL) were mixed with 7.5 ng/mL human Activin A, then added to MCP-11 cells. After 69 hours cell proliferation was measured and the linear portion of the curve was us used to calculate the ED50. The ED50 of Mouse Follistatin is between 0.13-0.19 ug/mL. This value is comparable to the typically expected to be less than 0.3 ug/mL.