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Proteins and Peptides

rHuman Flt-3 Ligand Protein

Product Sizes
100 ug
£898.00
009-F01-U86-0100-100UG
About this Product
SKU:
009-F01-U86-0100
Additional Names:
FLt3 L, Fms-related tyrosine kinase 3 ligand|FLT3LG
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
FMS-related Tyrosine Kinase 3 Ligand (FLT-3 Ligand) is a growth factor important for the proliferation of hematopoietic cells. FLT-3 Ligand binds to, and transmits signals through, the receptor tyrosine kinase known as FMS-like Tyrosine Kinase-3 (FLT-3). FLT-3 Ligand promotes long-term expansion and differentiation of human pro-B cells in the presence of IL-7 or in combination of IL-7 and IL-3. Human FLT-3 Ligand can stimulate the proliferation of cells expressing murine FLT-3 receptors. Recombinant human FLT-3 Ligand is a non-glycosylated protein, containing 155 amino acids, with a molecular weight of 17.7 kDa.
Immunogen:
FLT3LG
Physical State:
Lyophilized
Purity:
>98%
Shipping Conditions:
Ambient
Specificity:
FMS-related Tyrosine Kinase 3 Ligand is produced with no animal-derived raw products, animal free equipment and animal free protocols. Purity was determined to be greater than 98% as determined by analysis by HPLC, UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-PAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human FLT-3 Animal Free Ligand Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 ug Human FLT-3 Ligand AF in non-reducing conditions (-). Lane 3: Molecular weight marker. Lane 4: 1 ug Human FLT-3 Ligand AF in reducing conditions (+). Human FLT-3 Ligand AF has a predicted MW of 17.6 kDa.
Bioactivity of Human FLT-3 Ligand Animal Free Recombinant Protein. Serial dilutions of Human FLT-3 Ligand, starting at 1000 ng/mL, were added to primary Human PBMCs. After 48 hours human IL-6 was measure via ELISA and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human FLT-3 Ligand is 100-150 ng/mL.