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Proteins and Peptides

rHuman TRAIL Protein

Product Sizes
10 ug
£184.00
009-001-W34-0010-10UG
About this Product
SKU:
009-001-W34-0010
Additional Names:
Apo2 Ligand (Apo2L), TL2, TNF-related apoptosis-inducing ligand, CD253|TNFSF10
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
TNF-Related Apoptosis-Inducing Ligand (TRAIL) is produced by a wide variety of cell types and is shown to be a cytotoxic protein that induces apoptosis in tumor cells through activation of the death receptors, DR4 and DR5. Human TRAIL is active on mouse cells. Recombinant human TRAIL is a non-glycosylated protein, containing the 168 amino acid extracellular portion of TRAIL that is homologous to TNF. It has a molecular weight of 19.5 kDa.
Immunogen:
TNFSF10
Physical State:
Lyophilized
Purity:
>90%
Shipping Conditions:
Ambient
Specificity:
TRAIL purity was determined to be greater than 90% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human TRAIL Recombinant Protein. Lane 1: 1 ug Human TRAIL in non-reducing conditions (-). Lane 2: 1 ug Human TRAIL in reducing conditions (+). Lane 3: Molecular weight marker. Human TRAIL has a predicted MW of 19 kDa.
Bioactivity of Human TRAIL Recombinant Protein. RPMI-8226 cells were cultured with 0 to 500 ng/mL Human TRAIL. Cell proliferation was measured after 5 days and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human TRAIL is 10-15 ng/mL. This value is comparable to the competitor sample, but there is no typically accepted range for this assay.