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Proteins and Peptides

rHuman TNF Receptor-1 Protein

Product Sizes
100 ug
£728.00
009-001-W29-0100-100UG
About this Product
SKU:
009-001-W29-0100
Additional Names:
TNFRSF1A|Tumor necrosis factor receptor 1 (TNF-R1), Tumor necrosis factor receptor type 1, TNFAR, TNFR55, p55, p60, CD120a
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.01 M Sodium Phosphate
CE/IVD:
RUO
Extra Details:
TNF Receptor 1 (TNFR1) is expressed in most tissues and is activated by soluble and membrane-bound TNFA Alpha. TNFR1 is known to activate NF-kB and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis and inhibit viral replication. The soluble form of recombinant human TNFR1 is a non-glycosylated protein, containing 162 amino acids, with a molecular weight of 18.3 kDa.
Formulation:
0.01 M Sodium Phosphate, pH 7.5
Immunogen:
TNFRSF1A
Physical State:
Lyophilized
Purity:
>97%
Shipping Conditions:
Ambient
Specificity:
Tumor Necrosis Factor Receptor Type 1 purity was determined to be greater than 97% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Tumor Necrosis Factor Receptor Type 1 Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 ug Human TNF-Receptor 1 in non-reducing conditions (-). Lane 3: 1 ug Human TNF-Receptor 1 in reducing conditions (+). Human TNF-Receptor 1 has a predicted MW of 18.3 kDa.
Bioactivity of Human Tumor Necrosis Factor Receptor Type 1 Recombinant Protein. 929 cells were cultured with 1 ng/mL Human TNF-alpha and 1 ug/mL Actinomycin D, plus serial dilutions of Human TNF-Receptor 1 from 0-10 ug/mL. Cell proliferation was measured after 24 hours and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human TNF Receptor 1 is 8-12 ng/mL. This typical expected value for this activity is 9-45 ng/mL.