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Proteins and Peptides

rHuman SDF-1 alpha/CXCL12 Protein

Product Sizes
2 ug
£ POA
009-001-W22-0002-2UG
About this Product
SKU:
009-001-W22-0002
Additional Names:
C-X-C motif chemokine 12, Intercrine reduced in hepatomas (IRH, hIRH), Pre-B cell growth-stimulating factor (PBSF)|CXCL12
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Stromal cell Derived Factor-1 alpha (SDF-1A Alpha), also called CXCL12, is one of two splice variants made by a wide variety of cells when stimulated by inflammatory cytokines such as, TNF, IL-1 or LPS. SDF-1A Alpha signals through the G protein-couple receptor, CXCR4, to recruit activated leukocytes. Human and mouse SDF-1A Alpha share 99% sequence identity. Recombinant human SDF-1A Alpha is a non-glycosylated protein, containing 68 amino acids, with a molecular weight of 8 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
CXCL12
Physical State:
Lyophilized
Purity:
>98%
Shipping Conditions:
Ambient
Specificity:
Stromal Cell-Derived Factor-1 alpha (CXCL12) purity was determined to be greater than 98% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Stromal Cell-Derived Factor-1 alpha (CXCL12) Recombinant Protein. Lane 1: 1 ug Human SDF-1 alpha in non-reducing conditions (-). Lane 2: Molecular weight marker. Lane 3: 1 ug Human SDF-1 alpha in reducing conditions (+). Lane 4: Molecular weight marker. Human SDF-1 alpha has a predicted MW of 8 kDa.
Bioactivity of Human Stromal Cell-Derived Factor-1 alpha (CXCL12). Human T cells were allowed to migrate to Human SDF-1A Alpha at (0, 5, 20, 100, 500 ng/mL). After 4 hours, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Human SDF-1A Alpha detectable starting at between 5-20 ng/mL.
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