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Proteins and Peptides

rHuman Myostatin Propeptide Protein

Product Sizes
100 ug
£1087.00
009-001-W02-0100-100UG
About this Product
SKU:
009-001-W02-0100
Additional Names:
MSTN|Myostatin
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Concentration:
0.1 mg/ml
Extra Details:
Myostatin (GDF-8), a member of the TGF-B Beta superfamily, is a potent and specific negative regulator of skeletal muscle mass. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide acting as a negative regulator of myostatin. Recombinant human Myostatin Propeptide is a non-glycosylated protein, containing 244 amino acids, with a molecular weight of 27.8 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
MSTN
Physical State:
Lyophilized
Purity:
>95%
Shipping Conditions:
Ambient
Specificity:
Myostatin propeptide purity was determined to be greater than 95% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Myostatin Propeptide and Myostatin Recombinant Protein. Lane 1: 1 ug Human Myostatin Propeptide in reducing conditions (+). Lane 2: 1 ug Human Myostatin in reducing conditions (+). Lane 3: 1 ug Human Myostatin Propeptide in non-reducing conditions (-). Lane 4: 1 ug Human Myostatin in non-reducing conditions (-). Lane 5: Molecular weight marker. Human Myostatin Propeptide is predicted to be a disulfide-linked homodimer of 27.8 kDa and Myostatin is predicted to be a non-covalently linked homodimer with a MW of 25 kDa .
Bioactivity of Human Myostatin Propeptide Recombinant Protein. MPC-11 cells were cultured with 50 ng/mL Human Myostatin and serial dilutions of Human Myostatin Propeptide from 0-1 ug/mL. Cell proliferation was measured after 65 hours and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human Myostatin Propeptide is 0.09-0.14 ug/mL. This typical expected value for this activity is 10-40 ng/mL.