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Proteins and Peptides

rHuman Myostatin Protein

Product Sizes
100 ug
£1087.00
009-001-W01-0100-100UG
About this Product
SKU:
009-001-W01-0100
Additional Names:
GDF-8, Myostatin|Mstn
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Myostatin is a member of the TGF-B Beta superfamily that is essential for proper regulation of skeletal muscle mass in a number of species ranging from fish to humans. Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. Inhibition of myostatin can increase muscle mass in a number of animal models of human disease, including muscular dystrophy. Recombinant human Myostatin is a non-glycosylated homodimer, containing two 109 amino acid chains, with a total molecular weight of 24.8 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
Mstn
Physical State:
Lyophilized
Purity:
>95%
Shipping Conditions:
Ambient
Specificity:
Myostatin purity was determined to be greater than 95% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Myostatin Propeptide and Myostatin Recombinant Protein. Lane 1: 1 ug Human Myostatin Propeptide in reducing conditions (+). Lane 2: 1 ug Human Myostatin in reducing conditions (+). Lane 3: 1 ug Human Myostatin Propeptide in non-reducing conditions (-). Lane 4: 1 ug Human Myostatin in non-reducing conditions (-). Lane 5: Molecular weight marker. Human Myostatin Propeptide is predicted to be a disulfide-linked homodimer of 27.8 kDa and Myostatin is predicted to be a non-covalently linked homodimer with a MW of 25 kDa .
Bioactivity of Human Myostatin Recombinant Protein. MPC-11 cells were cultured with 0 to 500 ng/mL Human Myostatin. Cell viability was measured after 66 hours and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human Myostatin is 9.6-14.4 ng/mL. This value is expected to be less than 20 ng/mL.