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Proteins and Peptides

rHuman CCL13 Protein

Product Sizes
100 ug
009-001-V77-0100-100UG
About this Product
SKU:
009-001-V77-0100
Additional Names:
CCL13|CK-beta-10, Monocyte chemoattractant protein 4, Monocyte chemotactic protein 4 (MCP-4), NCC-1, Small-inducible cytokine A13
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Monocyte Chemotactic Protein 4 (MCP-4), also called CCL13, is induced by inflammatory proteins such as IL-1 and TNFA Alpha. MCP-4 is a ligand for three different G protein coupled receptors, CCR2, CCR3 and CCR5. MCP-4 activates signaling in monocytes, T lymphocytes, eosinophils and basophils and this signaling is associated with the allergic response. Recombinant human MCP-4 is a non-glycosylated protein, containing 74 amino acids, with a molecular weight of 8.5 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
CCL13
Physical State:
Lyophilized
Purity:
>95%
Shipping Conditions:
Ambient
Specificity:
Monocyte Chemotactic protein-4 (CCL13) purity was determined to be greater than 95% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Monocyte Chemotactic Protein-4 (CCL13) Recombinant Protein. Lane 1: 1 ug Human MCP-4 in non-reducing conditions (-). Lane 2: 1 ug Human MCP-4 in reducing conditions (+). Lane 3: Molecular weight marker. Human MCP-4 has a predicted MW of 8.6 kDa.
Bioactivity of Human Monocyte Chemotactic Protein-4 (CCL13) Recombinant Protein. Human THP-1 cells were allowed to migrate to Human MCP-4 at (0, 0.1, 1, 10, 100 and 1000 ng/mL). After 45 minutes, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Human MCP-4 starting at 1000 ng/mL. This value is comparable to expected ranges of a chemotactic response of primary human monocytes.