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Proteins and Peptides

rHuman IL-15 Protein

Product Sizes
100 ug
009-001-V53-0100-100UG
About this Product
SKU:
009-001-V53-0100
Additional Names:
IL-T|IL15
Application:
Cell-based/Functional Assay
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
Interleukin 15 (IL-15) is a widely expressed pro-inflammatory cytokine related to IL-2. IL-15 promotes activation of T cells, neutrophils and macrophages and is critical to dendritic cell function in several model systems. IL-15 has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggests that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells. Recombinant human IL-15 is a non-glycosylated protein, containing 114 amino acids, with a molecular weight of 12.8 kDa.
Immunogen:
IL15
Physical State:
Lyophilized
Purity:
>98%
Shipping Conditions:
Ambient
Specificity:
Interleukin-15 purity was determined to be greater than 98% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Bioactivity of Human Interleukin-15 Recombinant Protein. Serial dilutions of Human IL-15 (starting at 1 ng/mL) were added to CTLL-2 with other needed cytokines and stimuli. After 65 hours, cell viability was measured and the linear portion of the curve was us used to calculate the ED50. The ED50 of Lot # 0110-100-86 Human IL-15 is between 0.13- 0.19 ng/mL. This value is comparable to the typical expected range of < 0.5 ng/mL.