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Proteins and Peptides

rHuman IGF-II Protein

Product Sizes
10 ug
£184.00
009-001-V23-0010-10UG
About this Product
SKU:
009-001-V23-0010
Additional Names:
IGF2|Somatamedin A
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Insulin-like Growth Factor II, IGF-II, is a major growth hormone made by Theca cells during gestation. While IGF-II is known to engage the IGF-I receptor (IGF1R) to mediate embryonic growth, IGF-II is also known to bind the IGF-II receptor (IGF2R). IGF2R is thought to be signaling dead receptor that acts as a sink by binding up free IGF-II. Recombinant human IGF-II is non-glycosylated protein, containing 67 amino acids, with a molecular weight of 7.5 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
IGF2
Physical State:
Lyophilized
Purity:
>97%
Shipping Conditions:
Ambient
Specificity:
Insulin-like Growth Factor II purity was determined to be greater than 97% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Insulin-like Growth Factor II Recombinant Protein. Lane 1: 1 ug Human IGF-II in non-reducing conditions (-). Lane 2: 1 ug Human IGF-II in reducing conditions (+). Lane 3: Molecular weight marker. Human IGF-II has a predicted MW of 7.5 kDa.
Bioactivity of Human Insulin-like Growth Factor II Recombinant Protein. FDC-P1 cells were cultured with 0 to 250 ng/mL Human IGF-II. Cell proliferation was measured after 48 hours and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human IGF-II is 1.1-1.6 ng/mL. This value is comparable to the competitor sample and to the expected range of 1.5-6 ng/mL.