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Proteins and Peptides

rHuman Glial Derived NTF Protein

Product Sizes
100 ug
£1087.00
009-001-V10-0100-100UG
About this Product
SKU:
009-001-V10-0100
Additional Names:
ATF-1|GDNF
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a neurotrophic factor that is closely related to other neurotrophic factors, such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes RET and GFRA Alpha1-4, to promote dopamine uptake, survival and differentiation of neurons. Recombinant human GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.4 kDa.
Immunogen:
GDNF
Physical State:
Lyophilized
Purity:
>98%
Shipping Conditions:
Ambient
Specificity:
Glial Derived Neurotrophic Factor purity was determined to be greater than 98% as determined by analysis by HpLC, UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Glial Derived Neurotrophic Factor Recombinant Protein. Lane 1: 1 ug Human GDNF in non-reducing conditions (-). Lane 2: 1 ug Human GDNF in reducing conditions (+). Lane 3: Molecular weight marker. Human GDNF is predicted to be a disulfide linked homodimer having a total MW of 30.4 kDa.
Bioactivity of Human Glial Derived Neurotrophic Factor Recombinant Protein. C6 cells were cultured with 0 to 10 ug/mL Human GDNF. Cell proliferation was measured after 7 days and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human GDNF is 1.7-2.6 ug/mL.