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rHuman Galectin-3 Protein

Product Sizes
10 ug
£184.00
009-001-U92-0010-10UG
About this Product
SKU:
009-001-U92-0010
Additional Names:
35 kDa lectin, Galactose-specific lectin-3, Galactoside-binding protein (GALBP), IgE-binding protein, Laminin-binding protein, MAC2, L-29 CPB-35|LGALS3
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
Galectin-3 belongs to a large family of carbohydrate-binding proteins called lectins. Galectin-3 is expressed by a wide range of cell types including activated T cells, tumor cells, macrophages, osteoclasts, fibroblasts and epithelial cells and interacts with B Beta-galactoside sugar moieties. Galectin-3 is associated with cancer, heart failure, stroke and inflammation. Human and mouse Galectin-3 share an 80% homology by amino acid sequence. Recombinant human Galectin-3 is a non-glycosylated protein, containing 250 amino acids, with a molecular weight of 26 kDa.
Immunogen:
LGALS3
Physical State:
Lyophilized
Purity:
>97%
Shipping Conditions:
Ambient
Specificity:
Galectin-3 purity was determined to be greater than 97% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Lectins
SDS-PAGE of Human Galectin-3 Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 ug Human Galectin-3 in reducing conditions (+). Lane 3: Molecular weight marker. Lane 4: 1 ug Human Galectin-3 in non-reducing conditions (-). Human Galectin-3 has a predicted MW of 26 kDa.
Bioactivity of Human Galectin-3 Recombinant Protein. Human PBMCs were allowed to migrate to Human Galectin 3 at (0, 0.01, 0.1, 1, 10 and 100 ug/mL). After 1 hour, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Human Galectin 3 starting at 1 ug/mL. This value is comparable to expected ranges of a chemotactic response of primary human monocytes.