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rHuman Galectin-1 Protein

Product Sizes
10 ug
£184.00
009-001-U91-0010-10UG
About this Product
SKU:
009-001-U91-0010
Additional Names:
14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, S-LAC lectin-I, L-14|LGALS1
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
0.01 M Sodium Phosphate
CE/IVD:
RUO
Extra Details:
Galectin-1 belongs to a large family of carbohydrate-binding proteins called lectins. Galectin-1can be either monomeric or homodimeric and is found in a wide variety of cells and tissue types. Galectin-1 can control cell growth, proliferation, induce apoptosis of activated T cells while it can also modulate cytokine secretion or inhibit pro-inflammatory cytokine production. Galectin-1 plays an important role in acute and chronic inflammation. Recombinant human Galectin-1 is a non-glycosylated protein, containing134 amino acids, with a molecular weight of 14.5 kDa.
Formulation:
0.01 M Sodium Phosphate, pH 7.5
Immunogen:
LGALS1
Physical State:
Lyophilized
Purity:
>95%
Shipping Conditions:
Ambient
Specificity:
Galectin-1 purity was determined to be greater than 95% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Lectins
SDS-PAGE of Human Galectin-1 Recombinant Protein. Lane 1: 1 ug Human Galectin-1 in non-reducing conditions (-). Lane 2: 1 ug Human Galectin-1 in reducing conditions (+). Lane 3: Molecular weight marker. Human Galectin-1 has a predicted MW of 14.5 kDa.
Bioactivity of Human Galectin-1 Recombinant Protein. Human THP-1 cells were allowed to migrate to Human Galectin 1 at (0, 0.1, 1, 10, 100 and 1000 ng/mL). After 1 hour, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Human Galectin 1 starting at 100 ng/mL. This value is comparable to expected ranges of a chemotactic response at 2.5 ug/mL of primary human monocytes.