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Proteins and Peptides

rHuman Follistatin Protein

Product Sizes
100 ug
009-001-U88-0100-100UG
About this Product
SKU:
009-001-U88-0100
Additional Names:
FS, activin-binding protein, FSH-suppressing protein (FSP)|FST
Application:
Cell-based/Functional Assay, SDS-PAGE
Buffer:
See application note.
CE/IVD:
RUO
Extra Details:
Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide variety of TGF-beta family members (activin, BMPs, myostatin, GDF-11 and TGF-beta 1). Mechanistically, follistatin works as an antagonist by complexing with TGF-beta family members to prevent them from interacting with their signaling receptors. Recombinant human Follistatin is a non-glycosylated protein, containing 289 amino acids, with a molecular weight of 31.7 kDa.
Immunogen:
FST
Physical State:
Lyophilized
Purity:
>95%
Shipping Conditions:
Ambient
Specificity:
Follistatin purity was determined to be greater than 95% as determined by analysis by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SDS-PAGE of Human Follistatin Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 ug Human Follistatin in non-reducing conditions (-). Lane 3: 1 ug Human Follistatin in reducing conditions (+). Human Follistatin has a predicted MW of 31.7 kDa.
Bioactivity of Human Follistatin Recombinant Protein. MPC-11 cells were cultured with 0 to 1 ug/mL Human Follistatin with our without 7.5 ng/mL Human Activin A. Cell viability was measured after 66 hours and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human Follistatin is 30-50 ng/mL. Complete neutralization is seen by 250 ng/mL.