pTEN protein-GST fusion
Product Sizes
20 ug
£431.00
009-001-T08S-20UG
About this Product
- SKU:
- 009-001-T08S
- Additional Names:
- BZS, MHAM, TEP1, MMAC1, PTEN1, MGC11227, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog|PTEN
- Application:
- SDS-PAGE, Western Blot
- Buffer:
- See application note.
- CE/IVD:
- RUO
- Concentration:
- 0.2 ug/ul
- Extra Details:
- PTEN (phosphatase and tensin homolog) is a tumor suppressor that is frequently mutated in a large number of cancers (1). PTEN has phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase activity and contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates and is responsible for negatively regulating the intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells. PTEN functions as a tumor suppressor by negatively regulating the PI3K/AKT signaling pathway (2). PTEN protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Phosphatases, and WNT Signaling research.
- Immunogen:
- PTEN
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Specificity:
- Recombinant full-length human PTEN was expressed in E. coli cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >95% by densitometry.
- Storage Conditions:
- -70[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=009-001-T08S
