I kappaB alpha protein-GST fusion
Product Sizes
20 ug
£457.00
009-001-S18S-20UG
About this Product
- SKU:
- 009-001-S18S
- Additional Names:
- IKBA, NFKBIA, MAD-3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3|NFKBIA
- Application:
- Western Blot
- Buffer:
- See application note.
- CE/IVD:
- RUO
- Concentration:
- 0.2 ug/ul
- Extra Details:
- IkB-alpha is an inhibitor of the NFkB complex and inactivates the NFkB by trapping it in the cytoplasm (1). Phosphorylation of serine residues on the IkB protein by IkB kinases (IKKs) marks it for destruction via the ubiquitination pathway, thereby allowing the activation of the NFkB complex. Synthetic glucocorticoid such as dexamethasone display anti-inflammatory effects by inducing the increased synthesis of the IkB protein thereby inhibiting the activity of the NFkB complex. Overexpression of the IkB-alpha gene in fibroblasts leads to inhibition of production of IL-6, TNF receptor, MMP-1, MMP-3 and MMP-13 (2). IkB-alpha Protein is ideal for investigators involved in, Signaling Proteins, Transcription Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, and p38 Pathway research.
- Immunogen:
- NFKBIA
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Specificity:
- Recombinant human IkB-alpha (1-175) was expressed in E. coli cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >90% by densitometry.
- Storage Conditions:
- -70[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Isotype Controls
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=009-001-S18S
