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Proteins and Peptides

rHuman RANTES (CCL5) Protein

Product Sizes
20 ug
009-001-C20-0020-20UG
About this Product
SKU:
009-001-C20-0020
Additional Names:
CCL5|EoCP, Eosinophil chemotactic cytokine, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228 (TCP228), T-cell-specific protein RANTES
Application:
Cell-based/Functional Assay
Buffer:
0.1% Trifluoroacetic acid
CE/IVD:
RUO
Extra Details:
Regulated Upon Activation Normal T cell Express Sequence (RANTES), also called CCL5, is a chemokine produced by T cells three to five days after activation. RANTES is a promiscuous chemokine that signals through several G protein-coupled receptors, CCR5, CCR3, CCR1 and US28 (a viral receptor encoded by human CMV). The main function of RANTES is to recruit immune cells to the site of inflammation. Recombinant human RANTES is a non-glycosylated protein, containing 68 amino acids, with a molecular weight of 7.8 kDa.
Formulation:
0.1% Trifluoroacetic acid
Immunogen:
CCL5
Physical State:
Lyophilized
Purity:
>98%
Shipping Conditions:
Ambient
Specificity:
RANTES (CCL5) purity was determined to be greater than 98% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Bioactivity of Human RANTES (CCL5) Recombinant Protein. Human THP-1 cells were allowed to migrate to Human RANTES at (0, 0.1, 1, 10, 100 and 1000 ng/mL). After 45 minutes, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Human RANTES detectable starting at 10 ng/mL. These results are similar to results expected from primary human monocytes.