Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

Integrin alpha V + beta 6 Antibody

Product Sizes
20 ug
£364.00
RTM1-2500-P0-20UG
About this Product
SKU:
RTM1-2500-P0
Additional Names:
Vitronectin receptor | Vitronectin receptor subunit alpha
Application:
ELISA, Flow Cytometry, Immunofluorescence, Western Blot
translate.label.attr.clone:
AvB6 53a.2
Clonality:
Monoclonal
Extra Details:
Integrins are heterodimers composed of noncovalently associated transmembrane 伪 and 尾 subunits. The 16 伪 and 8 尾 subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix; including Fibronectin; Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen; or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs); leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization; integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes; including cell growth; differentiation; migration and apoptosis.
Host:
Rat
Immunogen:
Mouse fibroblasts retrovirally infected with cDNA to human beta6; Cells expressed a mouse/human avb6 chimera.
Isotype:
IgG2a
Molecular Weight:
150-160kDa under non-reducing conditions. Under reducing conditions|cleaved into 2 bands of ~125-130
Research Area:
Immunology; Lung Cancer; Signal Transduction
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody