CD137; Mouse Antibody
Product Sizes
20 ug
£364.00
RTM1-2012-P0-20UG
About this Product
- SKU:
- RTM1-2012-P0
- Additional Names:
- 4-1BB ligand receptor | T-cell antigen 4-1BB
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- LOB12
- Clonality:
- Monoclonal
- Extra Details:
- CD137 (4-1BB); a member of the tumor necrosis factor receptor superfamily; is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation; proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes; CD137 induces activation; promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.
- Host:
- Rat
- Immunogen:
- Murine CD137 human Fc fusion protein
- Isotype:
- IgG2a
- Molecular Weight:
- 39kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=126454
