MECA-79 Antibody
Product Sizes
20 ug
£364.00
RTM1-1599-P0-20UG
About this Product
- SKU:
- RTM1-1599-P0
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MECA-79
- Clonality:
- Monoclonal
- Extra Details:
- MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins; including sulfated ligands for CD62L (CD34; GlyCAM-1; Sgp200; and a subset of MAdCAM-1). This set antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1;3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues; chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with Mouse; human and many other species PNAd and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo.
- Host:
- Rat
- Immunogen:
- Mouse lymph node stromal cells
- Isotype:
- IgM
- Molecular Weight:
- 90-110kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=126423
