Recombinant HSV1 + HSV2 (Herpes Simplex Virus I & II) Antibody
Product Sizes
100 ug
£671.00
RBM1-12630-P1-100UG
About this Product
- SKU:
- RBM1-12630-P1
- Additional Names:
- ICP8 | UL29 | DBP | Major DNA-binding protein | US6 | gD | Envelope glycoprotein D
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- HSV/12630R
- Clonality:
- Monoclonal
- Extra Details:
- This recombinant rabbit monoclonal antibody cocktail is designed for the sensitive and specific detection of herpes simplex virus (HSV) by targeting two essential viral proteins: ICP8 from HSV-1 and glycoprotein D (gD) from HSV-1 and HSV-2. ICP8 is a single-stranded DNA-binding protein that plays a pivotal role in HSV-1 DNA replication; recombination; and repair; acting as a critical component of the viral replication machinery. It promotes homologous recombination; facilitates strand exchange; and interacts with multiple viral and host factors essential for viral genome processing. Glycoprotein D (gD) is a key envelope protein required for HSV attachment and entry into host cells; binding to specific cellular receptors and triggering membrane fusion. This interaction is essential for viral infectivity and determines host cell tropism; with gD mutations significantly altering viral entry efficiency. While both HSV-1 and HSV-2 utilize gD for cellular entry; HSV-2 is the predominant cause of genital herpes; a lifelong and incurable condition primarily transmitted through sexual contact. By simultaneously detecting ICP8 and gD; this antibody cocktail enables comprehensive HSV identification across serotypes; ensuring high sensitivity and specificity. The recombinant rabbit monoclonal format provides unmatched reproducibility and specificity; eliminating variability associated with traditional antibodies and making this cocktail an optimal choice for pathology and virology studies.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment corresponding to HSV-1 ICP8 protein and Recombinant fragment corresponding to HSV-1/2 glycoprotein D protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 59kDa; 128 kDa
- Research Area:
- Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=145374
