Recombinant SS18-SSX (Marker of Synovial Sarcoma) Antibody
Product Sizes
100 ug
£671.00
RBM1-12628-P1-100UG
About this Product
- SKU:
- RBM1-12628-P1
- Additional Names:
- Protein SYT; Synovial sarcoma translocated to X chromosome protein
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- SS18.SSX/12628R
- Clonality:
- Monoclonal
- Extra Details:
- S18 is a protein that has been shown to be a part of the SWI/SNF complex. The SS18-SSX fusion proteins are a result of in-frame fusions that fuse the SS18 gene on chromosome 18 with X chromosome genes SSX1; SSX2; and to a lesser extent SSX4. Human synovial sarcoma (SS) accounts for 8-10% of all soft tissue malignancies and 95% of these malignancies express the recurrent translocation of the SS18 gene on chromosome 18. The N-terminal SNH domain (SYT N-terminal homology domain) of the SS18 protein interacts with SWI/SNF chromatin remodeling complexes via the N terminal region of BRM and BRG1 subunits. Studies of the SS18-SSX fusion in SS suggest that endogenous SS18 competes with the mutant SS18-SSX fusion for occupancy in the SWI/SNF complexes resulting in the displacement of SNF5 (BAF47) subunit. Displacement of the SNF5 subunit results in altered function of the SWI/SNF complex that leads to deregulated expression of genes such as Sox2 in SS.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment corresponding to the fusion site of human SS18-SSX protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 65/75kDa
- Research Area:
- Epigenetics
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=142862
